| Autor: |
Sato, Koichi, Kon, Junko, Tomura, Hideaki, Osada, Mizuho, Murata, Naoya, Kuwabara, Atsushi, Watanabe, Tomoko, Ohta, Hideo, Ui, Michio, Okajima, Fumikazu |
| Zdroj: |
FEBS Letters; January 1999, Vol. 443 Issue: 1 p25-30, 6p |
| Abstrakt: |
Sphingosine 1‐phosphate (S1P) induces phospholipase C (PLC) activation and Ca2+mobilization in many types of cells. We examined the possible involvement of Edg‐3, one of the putative S1P receptors, in the phospholipase C (PLC)‐Ca2+system. S1P increased the cytoplasmic free Ca2+concentration without detectable inositol phosphate production in vector‐transfected CHO cells. In the Edg‐3‐transfected cells, however, the S1P‐induced Ca2+response was clearly enhanced, which was associated with a significant production of inositol phosphate. These S1P‐induced responses in the Edg‐3‐transfected cells were inhibited by U73122, a potent PLC inhibitor. We conclude that Edg‐3 may be one of the S1P receptors participating in the activation of the PLC‐Ca2+system. |
| Databáze: |
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