| Autor: |
Herrgård, Sanna, Jambeck, Per, Taylor, Susan S., Subramaniam, Shankar |
| Zdroj: |
FEBS Letters; December 2000, Vol. 486 Issue: 2 p107-111, 5p |
| Abstrakt: |
A‐kinase anchoring proteins (AKAPs) are adapter proteins that are involved in directing cAMP‐dependent protein kinase and some other signaling enzymes to certain intracellular locations. In this study, we investigate the domain architecture of an AKAP from Caenorhabditis elegans(AKAPCE). We show that AKAPCEshares two domains with the Smad anchor for receptor activation, a FYVE‐finger and a transforming growth factor β (TGFβ) receptor binding domain, suggesting that AKAPCEmay interact with a receptor belonging to the TGFβ receptor family. This predicted novel AKAP function supports the recent view of AKAPs as adapter proteins that can be involved in various signaling pathways. |
| Databáze: |
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