| Autor: |
Rankin, Sara, Morii, Narito, Narumiya, Shuh, Rozengurt, Enrique |
| Zdroj: |
FEBS Letters; November 1994, Vol. 354 Issue: 3 p315-319, 5p |
| Abstrakt: |
In this study we examined the role of rhop21 in neuropeptide‐stimulated tyrosine phosphorylation. Intact Swiss 3T3 cells were treated with the Clostridium botulinumC3 exoenzyme which specifically ADP ribosylates and inactivates rhop21. C3 exoenzyme treatment of cells caused a marked decrease in both bombesin‐ and endothelin‐stimulated tyrosine phosphorylation of multiple proteins, including p125 focal adhesion kinase (FAK) and paxillin. Our results suggest that rhop21 is a component of the signal transduction pathway linking seven transmembrane domain receptors with tyrosine phosphorylation and cytoskeletal events. |
| Databáze: |
Supplemental Index |
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