Effect of four i.v. induction agents on T-lymphocyte proliferations to PHA in vitro

Autor: DEVLIN, E.G., CLARKE, R.S.J., MIRAKHUR, R.K., MCNEILL, T.A.
Zdroj: British journal of anaesthesia : BJA; September 1994, Vol. 73 Issue: 3 p315-317, 3p
Abstrakt: Anaesthetic agents are believed to have an adverse effect on human immunity. We have studied the effects of four i.v. induction agents, thiopentone, methohexitone, etomidate and propofol, on T-lymphocyte proliferations to phytohaemagglutinin in vitro. We found that at plasma concentrations similar to those obtained after induction doses, all drugs, with the exception of propofol, caused depression of T-lymphocyte function.
Databáze: Supplemental Index