| Autor: |
Park, Byung-Jae, Lee, Duk-Gyu, Yu, Jae-Ran, Jung, Sun-ki, Choi, Kyuyeong, Lee, Jungsoo, Lee, Jiyeon, Kim, Yun Sik, Lee, Jin Il, Kwon, Jae Young, Lee, Junho, Singson, Andrew, Song, Woo Keun, Eom, Soo Hyun, Park, Chul-Seung, Kim, Do Han, Bandyopadhyay, Jaya, Ahnn, Joohong |
| Zdroj: |
Molecular Biology of the Cell; September 2001, Vol. 12 Issue: 9 p2835-2845, 11p |
| Abstrakt: |
Calreticulin (CRT), a Ca2+-binding protein known to have many cellular functions, including regulation of Ca2+homoeostasis and chaperone activity, is essential for heart and brain development during embryogenesis in mice. Here, we report the functional characterization of Caenorhabditis eleganscalreticulin (crt-1). Acrt-1null mutant does not result in embryonic lethality but shows temperature-dependent reproduction defects. In C. elegansCRT-1 is expressed in the intestine, pharynx, body-wall muscles, head neurons, coelomocytes, and in sperm. crt-1males exhibit reduced mating efficiency and defects late in sperm development in addition to defects in oocyte development and/or somatic gonad function in hermaphrodites. Furthermore, crt-1anditr-1(inositol triphosphate receptor) together are required for normal behavioral rhythms. crt-1transcript level is elevated under stress conditions, suggesting that CRT-1 may be important for stress-induced chaperoning function inC. elegans. |
| Databáze: |
Supplemental Index |
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