| Autor: |
Teng, Ellen C., Todd, Lance R., Ribar, Thomas J., Lento, William, Dimascio, Leah, Means, Anthony R., Sankar, Uma |
| Zdroj: |
Molecular Biology of the Cell; April 2011, Vol. 22 Issue: 8 p1312-1320, 9p |
| Abstrakt: |
Genes that promote hematopoietic stem cell (HSC) quiescence play important roles in the maintenance of their function. Here we show a novel role for the evolutionarily conserved flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase, growth factor erv1-like (Gfer) in the restriction of HSC proliferation through its inhibition of Jab1-mediated turnover of p27kip1. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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