MenaINVmediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis

Autor: Oudin, Madeleine J., Miller, Miles A., Klazen, Joelle A. Z., Kosciuk, Tatsiana, Lussiez, Alisha, Hughes, Shannon K., Tadros, Jenny, Bear, James E., Lauffenburger, Douglas A., Gertler, Frank B.
Zdroj: Molecular Biology of the Cell; October 2016, Vol. 27 Issue: 20 p3085-3094, 10p
Abstrakt: MenaINV, an actin-regulatory protein known to promote metastasis, has roles in driving cross-talk between extracellular matrix, growth factor cues, and their downstream pathways during tumor cell invasion. MenaINVis a shared component of the signaling pathway driving both EGF chemotaxis and fibronectin haptotaxis.
Databáze: Supplemental Index