| Autor: |
Fliss, Albert E., Fang, Yifang, Boschelli, Frank, Caplan, Avrom J. |
| Zdroj: |
Molecular Biology of the Cell; December 1997, Vol. 8 Issue: 12 p2501-2509, 9p |
| Abstrakt: |
The CDC37gene is essential for the activity of p60v-srcwhen expressed in yeast cells. Since the activation pathway for p60v-srcand steroid hormone receptors is similar, the present study analyzed the hormone-dependent transactivation by androgen receptors and glucocorticoid receptors in yeast cells expressing a mutant version of the CDC37gene. In this mutant, hormone-dependent transactivation by androgen receptors was defective at both permissive and restrictive temperatures, although transactivation by glucocorticoid receptors was mildly defective only at the restrictive temperature. Cdc37p appears to function via the androgen receptor ligand-binding domain, although it does not influence receptor hormone-binding affinity. Models for Cdc37p regulation of steroid hormone receptors are discussed. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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