High-sensitivity troponin in the evaluation of patients with suspected acute coronary syndrome: a stepped-wedge, cluster-randomised controlled trial

Autor: Shah, Anoop S V, Anand, Atul, Strachan, Fiona E, Ferry, Amy V, Lee, Kuan Ken, Chapman, Andrew R, Sandeman, Dennis, Stables, Catherine L, Adamson, Philip D, Andrews, Jack P M, Anwar, Mohamed S, Hung, John, Moss, Alistair J, O'Brien, Rachel, Berry, Colin, Findlay, Iain, Walker, Simon, Cruickshank, Anne, Reid, Alan, Gray, Alasdair, Collinson, Paul O, Apple, Fred S, McAllister, David A, Maguire, Donogh, Fox, Keith A A, Newby, David E, Tuck, Christopher, Harkess, Ronald, Parker, Richard A, Keerie, Catriona, Weir, Christopher J, Mills, Nicholas L, Marshall, Lucy, Stewart, Stacey D, Fujisawa, Takeshi, Vallejos, Catalina A, Tsanas, Athanasios, Hautvast, Mischa, McPherson, Jean, McKinlay, Lynn, Malo, Jonathan, Fischbacher, Colin M, Croal, Bernard L, Leslie, Stephen J, Walker, Allan, Wackett, Tony, Armstrong, Roma, Stirling, Laura, MacDonald, Claire, Sadat, Imran, Finlay, Frank, Charles, Heather, Linksted, Pamela, Young, Stephen, Alexander, Bill, Duncan, Chris
Zdroj: The Lancet; September 2018, Vol. 392 Issue: 10151 p919-928, 10p
Abstrakt: High-sensitivity cardiac troponin assays permit use of lower thresholds for the diagnosis of myocardial infarction, but whether this improves clinical outcomes is unknown. We aimed to determine whether the introduction of a high-sensitivity cardiac troponin I (hs-cTnI) assay with a sex-specific 99th centile diagnostic threshold would reduce subsequent myocardial infarction or cardiovascular death in patients with suspected acute coronary syndrome.
Databáze: Supplemental Index