| Autor: |
Hoyer, Nina, Zielke, Philip, Hu, Chun, Petersen, Meike, Sauter, Kathrin, Scharrenberg, Robin, Peng, Yun, Kim, Charles C., Han, Chun, Parrish, Jay Z., Soba, Peter |
| Zdroj: |
Cell Reports; August 2018, Vol. 24 Issue: 9 p2261-2272.e5 |
| Abstrakt: |
Dendrite morphogenesis is a highly regulated process that gives rise to stereotyped receptive fields, which are required for proper neuronal connectivity and function. Specific classes of neurons, including Drosophilaclass IV dendritic arborization (C4da) neurons, also feature complete space-filling growth of dendrites. In this system, we have identified the substrate-derived TGF-β ligand maverick(mav) as a developmental signal promoting space-filling growth through the neuronal Ret receptor. Both are necessary for radial spreading of C4da neuron dendrites, and Retis required for neuronal uptake of Mav. Moreover, local changes in Mav levels result in directed dendritic growth toward regions with higher ligand availability. Our results suggest that Mav acts as a substrate-derived secreted signal promoting dendrite growth within not-yet-covered areas of the receptive field to ensure space-filling dendritic growth. |
| Databáze: |
Supplemental Index |
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