| Abstrakt: |
Sato, Yoji, Max Harry Weil, Wanchun Tang, Shijie Sun, Jianlin Xie, Joe Bisera, and Hidehiro Hosaka. EsophagealPCO2as a monitor of perfusion failure during hemorrhagic shock. J. Appl. Physiol.82(2): 558–562, 1997.—Measurement of gastric wall PCO2(PgCO2) by tonometric method has emerged as an attractive option for estimating visceral perfusion during circulatory shock. However, gastric acid secretion obfuscates the tonometric measurement. We, therefore, investigated the option of measuringPCO2in the esophagus to minimize these restraints. Hemorrhagic shock was induced in five Sprague-Dawley rats, and five rats served as sham controls.PgCO2was measured with an ion-sensitive field effect transistor that was surgically implanted into the gastric wall. Esophageal luminalPCO2(PeCO2) was measured by a second ion-sensitive field effect transistor sensor. During hemorrhagic shock, mean aortic pressure declined from 150 to 50 mmHg. Gastric blood flow decreased from 58 to 12 ml ⋅ min−1⋅ 100 g−1(21% of preshock) and esophageal blood flow from 44 to 7 ml ⋅ min−1⋅ 100 g−1(16% of preshock).PgCO2simultaneously increased from 47 to 116 Torr andPeCO2from 47 to 127 Torr. The increases inPgCO2were highly correlated with increases inPeCO2(r= 0.90). Esophageal tonometry may, therefore, serve as a practical alternative to gastric tonometry. |
