| Abstrakt: |
Charan, Nirmal B., and Paula Carvalho. Angiogenesis in bronchial circulatory system after unilateral pulmonary artery obstruction. J. Appl. Physiol.82(1): 284–291, 1997.—We studied the effects of left pulmonary artery (LPA) ligation on the bronchial circulatory system (BCS) by using a sheep model. LPA was ligated in the newborn lambs soon after birth (n= 8), and when the sheep were ∼3 yr of age anatomic studies revealed marked angiogenesis in BCS. Bronchial blood flow and cardiac output were studied by placing flow probes around the bronchial and pulmonary arteries in four adult sheep. After LPA ligation, bronchial blood flow increased from 35 ± 6 to 134 ± 42 ml/min in ∼3 wk (P< 0.05). We also studied gas-exchange functions of BCS ∼3 yr after the ligation of LPA in newborn lambs (n= 4) and used a control group (n= 12) in which LPA was ligated acutely. In the left lung, O2uptake after acute ligation was 16 ± 3 ml/min and was similar to the chronic model, whereas CO2output in the control group was 27 ± 3 ml/min compared with 79 ± 12 ml/min in the chronic preparation (P< 0.05). We conclude that LPA ligation causes marked angiogenesis in BCS that is capable of performing some gas-exchange functions. |
