| Autor: |
Codee, J. D. C., Bos, L. J. van den, Litjens, R. E. J. N., Overkleeft, H. S., Boom, J. H. van, Marel, G. A. van der |
| Zdroj: |
Organic Letters; May 2003, Vol. 5 Issue: 11 p1947-1950, 4p |
| Abstrakt: |
A novel sequential glycosylation procedure is described that combines the use of 1-hydroxyl and thiodonors. The Ph2SO/Tf2O-mediated dehydrative condensation of 1-hydroxyl donors with thioglycosides affords in good yield the thiodisaccharides, which in turn can be activated by the same activator system to furnish trisaccharides. The α-Gal epitope and a hyaluronan trisaccharide were efficiently assembled in a one-pot procedure. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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