| Autor: |
Chamnanphon, Monpat, Gaedigk, Andrea, Vanwong, Natchaya, Nuntamool, Nopphadol, Hongkaew, Yaowaluck, Puangpetch, Apichaya, Sukasem, Chonlaphat |
| Zdroj: |
Pharmacogenomics; July 2018, Vol. 19 Issue: 12 p947-960, 14p |
| Abstrakt: |
The highly polymorphic CYP2D6gene locus leads to a wide range of enzyme activity. Since there are limited data for Thai, the major aim was to investigate CYP2D6genetic variation in a large Thai population (n 920). CYP2D6genotyping was performed using four different platforms. Genotype call rates of the Luminex xTAG®and AmpliChip CYP450 test were 96.5 and 87.4, respectively. Based on Luminex xTAG®data, the most common alleles and genotypes were 1 0(49.6), 1(24.6), 2(10.8), 5(6.7), 41(6.5) and 1/10(23.9), 10/10(21.5), 2/10(9.4), 5/10(6.9), 10/41(5.7), respectively. Challenges and limitations of the platforms evaluated are discussed. These data add to our knowledge regarding interethnic variability in CYP2D6 activity and contribute to improving drug therapy in the Thai. |
| Databáze: |
Supplemental Index |
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