| Autor: |
Inoue, Shuji, Satoh, Shinobu, Saito, Mari, Naitoh, Makoto, Suzuki, Hiroyo, Egawa, Makoto |
| Zdroj: |
Obesity Research; December 1995, Vol. 3 Issue: Supplement 5 p747S-752S, 6p |
| Abstrakt: |
Effects of hepatic and celiac vagotomy on circadian rhythms of plasma glucose, insulin, and food intake were examined in sham‐operated (control) and vetromedial hypothalamic (VMH) lesioned rats. Rats were acclimated to the condition with a 12‐hour light‐dark cycle for 1 week before surgery. One week after VMH lesions, control and VMH lesioned rats were divided into three groups: sham vagotomy, hepatic vagotomy, and celiac vagotomy. Three days after vagotomy, food intake was measured at 6‐hour intervals. Seven days after vagotomy, plasma glucose and insulin were measured at the midpoint of each feeding period. In control rats, hepatic vagotomy destroyed circadian rhythms of plasma glucose and insulin probably due to removal of afferent function. In VMH lesioned rats, celiac vagotomy destroyed circadian rhythm of food intake due to the reduction of plasma insulin by removal of efferent function without affecting the loss of circadian rhythms of plasma glucose and insulin. |
| Databáze: |
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