| Autor: |
Petroianu, Georg, Szőke, Éva, Kalász, Huba, Szegi, Péter, Laufer, Rudolf, Benkő, Bernadett, Darvas, Ferenc, Tekes, Kornélia |
| Zdroj: |
The Open Medicinal Chemistry Journal; November 2009, Vol. 3 Issue: 1 p1-7, 7p |
| Abstrakt: |
Three major flavonoid chamomile components (quercetin, apigenin-7-O-glucoside and rutin) were subjected to oxidative metabolism by cytochrome P-450 of rat liver microsomal preparations. Changes over time in their respective concentrations were followed using reversed-phase HPLC with UV detection. No clean-up had to be applied as only the specific flavonoid had to be separated from the background components originating from the rat liver microsome.Neither the concentration of apigenin-7-O-glucoside nor that of the diglycoside rutin decreased during one hour of exposure to rat microsomal treatment. In contrast, the concentration of quercetin, a lipophilic aglycon, decreased.Our analytical HPLC results complement the calculated lipophilicity (logP) of these compounds; the relatively high lipophilicity of quercetin appears to predispose it to oxidative metabolism in order to decrease its fat solubility. In contrast the much less lipophilic compounds apigenin-7-O-glucoside and rutin were resistant to microsomal treatment.in silicoin vitro |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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