| Autor: |
Koyama, Michinori, Hashimoto, Mariko, Asakawa, Noriko, Ishibashi, Masataka, Miyazaki, Hiroshi |
| Zdroj: |
Biomedical Mass Spectrometry; September 1980, Vol. 7 Issue: 9 p372-376, 5p |
| Abstrakt: |
A specific and sensitive method for the simultaneous determination of bestatin and its major metabolite, p-hydroxybestatin in human serum has been developed by selected ion monitoring using the corresponding deuterated internal standards. The N-trifluoroacetamide-O-trimethylsilyl ether derivatives of the trideuteromethyl esters of bestatin and p-hydroxybestatin were suitable for quantitation by selected ion monitoring. The determination limit of these compounds by the present method is 1 ng ml-1in human serum. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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