| Autor: |
Baty, J. D., Price-Evans, D. A., Gilles, H. M., Greaves, J. |
| Zdroj: |
Biomedical Mass Spectrometry; January 1978, Vol. 5 Issue: 1 p76-79, 4p |
| Abstrakt: |
Several substituted 8-aminoquinolines related to known antimalarial drugs have been studied by gas chromatography mass spectrometry. 5,6-Dihydroxy-8-aminoquinoline, a possible metabolite of Primaquine, can be detected by single ion monitoring after conversion to a trimethylsilyl ether derivative. The mass spectra obtained in this study indicate that there are certain ions which are characteristic of the trimethylsilyl ethers of hydroxylated 8-aminoquinolines and 5,6-dimethoxy-8-aminoquinolines. These compounds should thus be amenable to analysis if they were produced during in vivometabolism studies. Using selected ion monitoring the derivatized compounds can be detected at submicrogram levels. |
| Databáze: |
Supplemental Index |
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