NEDD9 targets COL3A1to promote endothelial fibrosis and pulmonary arterial hypertension

Autor: Samokhin, Andriy O., Stephens, Thomas, Wertheim, Bradley M., Wang, Rui-Sheng, Vargas, Sara O., Yung, Lai-Ming, Cao, Minwei, Brown, Marcel, Arons, Elena, Dieffenbach, Paul B., Fewell, Jason G., Matar, Majed, Bowman, Frederick P., Haley, Kathleen J., Alba, George A., Marino, Stefano M., Kumar, Rahul, Rosas, Ivan O., Waxman, Aaron B., Oldham, William M., Khanna, Dinesh, Graham, Brian B., Seo, Sachiko, Gladyshev, Vadim N., Yu, Paul B., Fredenburgh, Laura E., Loscalzo, Joseph, Leopold, Jane A., Maron, Bradley A.
Zdroj: Science Translational Medicine; June 2018, Vol. 10 Issue: 445
Abstrakt: TGF-β–independent oxidative modification of NEDD9 at Cys18promotes vascular fibrosis and the pathobiology of pulmonary arterial hypertension.
Databáze: Supplemental Index