| Autor: |
Choma, Christin T., Robillard, George T., Englebretsen, Darren R. |
| Zdroj: |
Tetrahedron Letters; January 1998, Vol. 39 Issue: 16 p2417-2420, 4p |
| Abstrakt: |
The development of an Fmoc method for synthesis and purification of hydrophobic peptides using a “solubilising tail” strategy is described. Peptide-constructs of the form hydrophobic peptide-[4-Hmb ester]-solubilising peptide were synthesised. Procedures for forming the 4-Hmb ester linkage, and sequences of solubilising peptides suitable for use with Fmoc SPPS, were investigated. The method was used to synthesise two model peptides and three designed transmembrane peptides. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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