| Autor: |
Czollner, Laszlo, Frantsits, Werner, Küenburg, Bernhard, Hedenig, Ursula, Fröhlich, Johannes, Jordis, Ulrich |
| Zdroj: |
Tetrahedron Letters; January 1998, Vol. 39 Issue: 15 p2087-2088, 2p |
| Abstrakt: |
A concise, scalable synthesis of (−)-galanthamine, a drug being used for the treatment of Alzheimer's disease, is described. The yield of the critical phenolic coupling step was optimized to 45–50%. For the reduction of the aryl bromide, air-activated LiAIH 4was used and racemic narwedine was converted to (−)-narwedine by a second order asymmetric transformation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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