Remarkable effects of donor esters on the α-chymotrypsin-catalyzed couplings of inherently poor amino acid substrates

Autor: Miyazawa, Toshifumi, Tanaka, Kayoko, Ensatsu, Eiichi, Yanagihara, Ryoji, Yamada, Takashi
Zdroj: Tetrahedron Letters; January 1998, Vol. 39 Issue: 9 p997-1000, 4p
Abstrakt: The extremely low efficiency during the α-chymotrypsin-catalyzed coupling of an inherently poor amino acid substrate, e.g., alanine, using the methyl ester as an acyl donor was significantly improved using esters such as the 2,2,2-trifluoroethyl or carbamoylmethyl ester. The ameliorating effect of the latter ester was especially significant.
Databáze: Supplemental Index