| Autor: |
Shuker, Anthony J., Siegel, Miles G., Matthews, Donald P., Weigel, Leland O. |
| Zdroj: |
Tetrahedron Letters; September 1997, Vol. 38 Issue: 35 p6149-6152, 4p |
| Abstrakt: |
A 48 compound library of structurally diverse ethanolamines was prepared using a parallel synthesis approach. The synthetic paradigm employed a solution phase epoxide-opening reaction followed by rapid purification by ion exchange chromatography to yield products with near-analytical purity. An array of epoxides and primary amines, arranged in an 8×6 matrix, were reacted in the presence of an in situ silylating agent to form 48 individual compounds with an average yield of 75% and an average purity of 92.3%. © 1997 Elsevier Science Ltd. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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