| Autor: |
D'Ambra, Thomas E., Javitt, Norman B., Nakanishi, Koji, Warchol, Tadeusz |
| Zdroj: |
Tetrahedron Letters; January 1997, Vol. 38 Issue: 22 p3801-3804, 4p |
| Abstrakt: |
A new, convenient and stereoselective route to the synthesis of (25R)-cholest-5-ene-3β,26-diol ( 1) and its radiolabeled analog 4is described. The key step is a Julia condensation of sulfone 6with aldehyde 12to furnish compound 13. Further reduction of the α-hydroxysulfone moiety afforded 22,23-unsaturated i-steroid 14. The double was reduced by hydrogen and by tritium to provide substrates for the preparation of 1and 4, respectively. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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