| Autor: |
Dhokte, Ulhas P., Khau, Vien V., Hutchison, Darrell R., Martinelli, Michael J. |
| Zdroj: |
Tetrahedron Letters; January 1998, Vol. 39 Issue: 48 p8771-8774, 4p |
| Abstrakt: |
Acyclic and a highly efficient stereoselective C C bond formation of aldehyde 3with the crotylboron reagent 4, derived from (−)-α-pinene, provided a homoallylic alcohol 6in ≥99% enantio-(ee) and diastereomeric excess (de). The alcohol 6was linearly converted into the desired Fragment A 10of cryptophycins in seven steps. This enantiomerically pure Fragment A was conveniently and efficiently coupled with the other three fragments, namely B, C and D, and provided the desired cryptophycin A derivative ( LY404291). The terminal double bond in LY404291was further elaborated to provide a terminal epoxide LY404292, and cryptophycins 51and 52. |
| Databáze: |
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