Structure elucidation of Sch 49088, a novel everninomicin antibiotic containing an unusual hydroxylamino-ether sugar, everhydroxylaminose

Autor: Saksena, Anil K., Jao, Edwin, Murphy, Bruce, Schumacher, Doris, Chan, Tze-Ming, Puar, Mohindar S., Jenkins, John K., Maloney, Donal, Cordero, Mayra, Pramanik, Birendra N., Bartner, Peter, Das, Pradip R., McPhail, Andrew T., Girijavallabhan, V.M., Ganguly, Ashit K.
Zdroj: Tetrahedron Letters; January 1998, Vol. 39 Issue: 46 p8441-8444, 4p
Abstrakt: Degradation of Sch 49088 ( 1) provided a novel, highly functionalized O-substituted hydroxylamine-containing sugar, everhydroxylaminose 11isolated as a β-OMe glycoside. Notably the two acid sensitive orthoester moieties in the intact antibiotic 1co-exist in the presence of three phenolic groups and a free carboxylic acid group.
Databáze: Supplemental Index