An efficient high-speed synthetic route to amino-substituted thiazolidinone libraries

Autor: Munson, Mark C., Cook, Adam W., Josey, John A., Rao, Chang
Zdroj: Tetrahedron Letters; January 1998, Vol. 39 Issue: 40 p7223-7226, 4p
Abstrakt: An efficient solid-phase synthesis of amino-substituted thiazolidinones using an acid-labile carbamate linkage is reported. In this approach, excess unprotectedsymmetrical diamine is incorporated directly onto a carbonylimidazole activated Wang support followed by imine formation on the remaining free primary amine, cyclization and amide bond expansion.
Databáze: Supplemental Index