Enantioselective synthesis of highly functionalised cyclohexanones starting from R-(−)-carvone

Autor: Meulemans, Tommi M., Stork, Gerrit A., Jansen, Ben J.M., de Groot, Aede
Zdroj: Tetrahedron Letters; January 1998, Vol. 39 Issue: 36 p6565-6568, 4p
Abstrakt: Copper ( I) catalysed conjugate addition of methylmagnesium iodide to R-(−)-carvone and trapping the enolate as its trimethylsilyl enol ether, followed by a trityl perchlorate (TrClO 4) catalysed Mukaiyama-aldol reaction, is an efficient method for the preparation of highly functionalised cyclohexanones which can be used as starting compounds in the total syntheses of enantiomerically pure clerodanes.
Databáze: Supplemental Index