Kinetic resolution of secondary alcohols mediated by rabbit gastric lipase

Autor: Legros, Jean-Yves, Toffano, Martial, Drayton, Sally K., Rivard, Michael, Fiaud, Jean-Claude
Zdroj: Tetrahedron Letters; January 1997, Vol. 38 Issue: 11 p1915-1918, 4p
Abstrakt: Secondary benzylic alcohols were kinetically resolved by rabbit gastric lipase-mediated acylation with isopropenyl acetate. Among all the substrates tested, a high enantioselectivity was observed only for 1-[2-(6-methoxy)naphthyl]ethanol 3a( E>500). Allylic alcohols 14aand 15awere also efficiently resolved (E = 26 and 51 respectively).
Databáze: Supplemental Index