An efficient synthesis of a Galβ1-3GalNAc-Serine derivative using β-galactosidase

Autor: Suzuki, Katsuhiko, Fujimoto, Hiroshi, Ito, Yoshiyuki, Sasaki, Takashi, Ajisaka, Katsumi
Zdroj: Tetrahedron Letters; January 1997, Vol. 38 Issue: 7 p1211-1214, 4p
Abstrakt: An efficient route for the synthesis of Galβ1-3GalNAcα1- O-Serine derivative was developed using a novel β1-3 galactosidase obtained from Bacillus circulans. By a transglycosylation reaction with pNP-β-Gal 2as a donor and GalNAcα1- O-Z-Ser-OAll 4as an acceptor, Galβ1-3GalNAcα-1- O-Z-Ser-OAll 5was synthesized in 68% yield.
Databáze: Supplemental Index