Bis-esters from maleic anhydrides under neutral conditions: Protection of the anhydride of the natural product cornexistin

Autor:	Fields, Stephen C., Dent, William H., Green, F.Richard, Tromiczak, Eric G.
Zdroj:	Tetrahedron Letters; January 1996, Vol. 37 Issue: 12 p1967-1970, 4p
Abstrakt:	Trimethylsilyldiazomethane converts maleic anhydride derivatives in alcoholic THF to bisesters. The highly acid and base sensitive natural product cornexistin was converted to its bis-methyl ester in 70–75% yield and to the mixed benzyl/methyl ester in 61% yield. The mixed ester can be converted back to cornexistin via transfer hydrogenation.
Databáze:	Supplemental Index
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