An expeditious synthesis of a biscyclam with an aromatic linker

Autor: Xu, Daqiang, Mattner, Paul G., Prasad, Kapa, Repic, Oljan, Blacklock, Thomas J.
Zdroj: Tetrahedron Letters; January 1996, Vol. 37 Issue: 30 p5301-5304, 4p
Abstrakt: An efficient synthesis of 1starting from N,N′-bis(3-aminopropyl)ethylenediamine 2is described. Two salient features of the present work are the selective bis or tris-trifluoracetylation of 2and a novel bis-macrocyclization of the hexatosyl intermediate 5using ethylene glycol ditosylate.
Databáze: Supplemental Index