Protection, metalation, and electrophilic substitution of 5-methyl tetrazole

Autor: Huff, Bret E., LeTourneau, Michael E., Staszak, Michael A., Ward, Jeffrey A.
Zdroj: Tetrahedron Letters; January 1996, Vol. 37 Issue: 21 p3655-3658, 4p
Abstrakt: 5-Methyl tetrazole was N-protected with the trityl group and deprotonated using n-BuLi. The resulting 5-methyl anion was trapped with a variety of electrophiles to provide 5-substituted tetrazoles in good yields. The trityl protecting group was readily removed using HCl in methylene chloride.
Databáze: Supplemental Index