| Autor: |
Guida, Michele, Casamassima, Addolorata, Marzullo, Franco, Addabbo, Lucrezia, Filotico, Raffaele, Lorusso, Vito |
| Zdroj: |
Tumori Journal; June 1991, Vol. 77 Issue: 3 p273-276, 4p |
| Abstrakt: |
The authors describe a case of primary central nervous system lymphoma In a 43-year-old male. Interest in this rare form of B-lymphocyte non-Hodgkin's lymphoma is due to its increasing incidence in the last decade, especially in immunodeficient patients. Extraneural involvement was excluded by staging examinations: bilateral bone marrow biopsy from the posterior iliac crest, bipedal lymphography, abdominal CT scan, skeletal, thoracic and gastrointestinal X-rays, spinal puncture, ORL and clinical examination. The peripheral immunologic state was particularly interesting: there was a substantial decrease in total circulating B-lymphocytes at diagnosis (4.4 % = 80/mmc; nv 13 ± 4 % = 287 ± 130/mmc) and a further decrease after 2 and 4 months of therapy (0.16% = 2/mmc). Three months after completion of therapy, the B-lymphocyte level returned to the base level at diagnosis (7 % = 88/mmc). At 10 months after diagnosis and 3 months after completion of chemotherapy, the patient is alive and in good health except for the after-effects of a left hemiparesis. The etiologic and possible pathogenic factors are considered. |
| Databáze: |
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