| Autor: |
Nervi, Carlo, Casale, Carlo, Cortese, Massimo |
| Zdroj: |
Tumori Journal; May 1969, Vol. 55 Issue: 3 p153-159, 7p |
| Abstrakt: |
Tissue hyperoxygenation is an important factor in enhancing the antitumor activity of cytotoxic agents. The authors describe their technique for regional hyperoxygenation by intrarterial infusion of hydrogen peroxide combined with anticancer agents. The method was tried in 34 patients with extensive head and neck tumors. Objective regression was obtained in 19 (55.7 %). Hyperoxygenation probably influences the cellular metabolic and enzymatic processes, thus enhancing the antineoplastic activity of cytotoxic agents. The method described is useful either as a palliative in extensive inoperable tumors, especially those previously irradiated, or as a first chemotherapeutic step in a comprehensive program of treatment in resistant, slow-growing tumors. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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