| Autor: |
Stasi, Roberto, Tribalto, Maurizio, Venditti, Adriano, Del Poeta, Giovanni, Aronica, Germano, Zaccar, Giuseppe, Rossi, Vincenza, Maffei, Laura, Papa, Giuseppe |
| Zdroj: |
Tumori Journal; December 1992, Vol. 78 Issue: 6 p403-406, 4p |
| Abstrakt: |
A 52-year-old woman, previously treated with chemo- and radiotherapy for Hodgkin's disease, developed an acute non-lymphoid leukemia and, contemporarily, an IgG-kappa paraproteinemia. Cytogenetic analysis showed a major clone, representing 90% of observed metaphases, with monosomy of chromosomes 5 and 14. In addition, leukemic cells exhibited a high expression of the P-glycoprotein, a transmembrane glycoprotein involved in the multidrug-resistance mechanism. Possible explanations for this cluster of findings are provided. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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