Synthesis and Antibacterial Activity of 6-O-Arylbutynyl Ketolides with Improved Activity against Some Key Erythromycin-Resistant Pathogens
| Autor: | Keyes, R. F., Carter, J. J., Englund, E. E., Daly, M. M., Stone, G. G., Nilius, A. M., Ma, Z. |
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| Zdroj: | Journal of Medicinal Chemistry; May 2003, Vol. 46 Issue: 10 p1795-1798, 4p |
| Abstrakt: | A series of novel 6-O-substituted homopropargyl ketolides was synthesized and evaluated against various erythromycin-resistant pathogens. Promising in vitro antibacterial activity was demonstrated for compounds bearing this structural motif. |
| Databáze: | Supplemental Index |
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