| Autor: |
Demicheli, Romano, Foroni, Roberto, Giuliani, Fernando C., Savi, Giuseppina |
| Zdroj: |
Tumori Journal; June 1988, Vol. 74 Issue: 3 p269-274, 6p |
| Abstrakt: |
The influence of tumor growth kinetics on response to doxorubicin treatment of C3H mammary carcinoma was investigated. Gompertzian growth curves were obtained for the tumor mass of each mouse by a computerized best fit program. The response was assessed by evaluating: a) the total clonogenic cell reduction as a fraction of the initial tumor volume or the tumor volume that should result at the end of treatment in a free growth condition, and b) the partial clonogenic cell reduction at each drug administration, assuming a first order cell kill hypothesis. Slowly growing tumors at each dose level showed a significantly poorer response than rapidly growing tumors. Each response index exhibited a linear correlation with the specific instantaneous growth rate at the time of treatment. Data also suggested a dose-response dependence. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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