| Autor: |
Rovini, Dario, Sacchini, Virgilio, Codazzi, Virginia, Vaglini, Maurizio, Illeni, Maria Teresa |
| Zdroj: |
Tumori Journal; February 1984, Vol. 70 Issue: 1 p29-33, 5p |
| Abstrakt: |
Two groups of malignant melanoma (MM) patients were considered: the group of 140 patients previously published and a new one of 58, both typed for HLA-A, -B and -C antigens at the Istituto Nazionale Tumori of Milan. The control group consisted of healthy blood donors not related to the patients. Only the HLA-Bw35 antigen frequency was significantly decreased in both groups of patients. To investigate the HLA-A and -B blanks, 62 MM patients and 90 healthy controls, who showed non-homozygotic blanks when they were firstly HLA typed, volunteered to repeat the HLA typging three or more times in a 2-year period. A significant increase in both HLA-A and -B blanks in the patients as compared to controls was noticed (p = 3 × 10−4and 3 × 10−5, respectively). In the future, attempts should be made to correlate the HLA antigen and blank frequencies with the evolution of the disease and, also, to verify the hypothesis that the HLA-Bw35 antigen may be an associated resistance factor against the tumor. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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