| Autor: |
Conte, Pier Franco, Bruzzone, Milena, Chiara, Silvana, Rosso, Riccardo, Giaccone, Giuseppe, Carnino, Flavio, Guercio, Elso, Ragni, Nicola, Foglia, Gianni, Bentivoglio, Giorgio, Pescetto, Giuseppe, Materman, Eric, Franks, Chris |
| Zdroj: |
Tumori Journal; April 1988, Vol. 74 Issue: 2 p217-220, 4p |
| Abstrakt: |
Eleven untreated patients with advanced ovarian cancer were studied for tolerance and response to combination treatment with fixed doses of adriamycin (45 mg/m2) and cyclophosphamide (600 mg/m2) + escalating doses of carboplatin. At the first dose level of carboplatin (200 mg/m2), toxicity was acceptable. With carboplatin at 300 mg/m2, severe hematologic toxicity was observed. The dose-limiting toxicity was leukopenia. Although carboplatin was administered without any hydration, no patient experienced renal toxicity. Eight objective responses were observed in 9 clinically evaluable patients. At second look surgery, 3 complete responses and 4 partial responses were documented. Polychemotherapy with JAC (carboplatin, 200 mg/m2, adriamycin, 45 mg/m2, and cyclophosphamide, 600 mg/m2) is administrable with acceptable toxicity. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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