| Autor: |
Barck, Charlotte, Lundahl, Joachim, Holmström, Mats, Bylin, Gunnar |
| Zdroj: |
American Journal of Rhinology & Allergy; November 2005, Vol. 19 Issue: 6 p560-566, 7p |
| Abstrakt: |
Background Exposure to high ambient levels of nitrogen dioxide (NO2) enhances the bronchial inflammatory reaction to allergen in humans. We tested whether this NO2effect occurs also in the upper airways.Methods Sixteen allergic subjects with rhinitis and mild asthma were exposed at rest to either purified air or 500 μg/m3NO2for 30 minutes, followed 4 hours later by a nasal allergen challenge. Nasal lavage was performed before air/NO2exposure, before allergen challenge, and 1, 4 and 18 hours after allergen challenge. Symptoms were recorded.Results The percentage of eosinophils and neutrophils, eosinophil cationic protein, and myeloperoxidase were similar after exposure to air + allergen and to NO2+ allergen. We noticed a tendency to increased sneezing the day after exposure to NO2+ allergen.Conclusion The priming effect of an ambient brief NO2exposure on subsequent allergic response was not noticeable in activation of inflammatory cells and mediators in the upper airways. |
| Databáze: |
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