| Autor: |
Lang, Amy S., Burkeholder, Susan B., Park, Michael H., Ordonez, Guido A., Cooper, Barry, Piñeiro, Luis A., Stone, Marvin J. |
| Zdroj: |
Baylor University Medical Center Proceedings; April 1998, Vol. 11 Issue: 2 p77-79, 3p |
| Abstrakt: |
A 47-year-old woman (MC) with severe anemia and red cell aplasia was found to have a serum monoclonal immunoglobulin component (M-component) but no evidence of overt multiple myeloma. The patient was treated with cyclophosphamide and prednisone, resulting in normalization of red cell values and a 75% reduction in the level of serum M-component. A colony-growth assay demonstrated specific inhibition of normal burst-forming unit-erythroid formation in the presence of a concentration of the patient's purified immunoglobulin, which approximated 60% of its plasma level at presentation. Burst-forming unit-erythroid colony-growth inhibition was not seen with the addition of similar concentrations of normal pooled immunoglobulin or another monoclonal immunoglobulin from a myeloma patient (DK). These results suggest that the monoclonal immunoglobulin from patient MC was an antibody to erythroid precursor cells. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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