Extensive Neurophisyological Evaluation in Primary Premature Ejaculation Patients

Autor: Imbimbo, C., Granata, A.M., Buonopane, R., Barba, C., Ranavolo, R., Cicalese, A.R., Mirone, V.
Zdroj: Urologia; January 2004, Vol. 71 Issue: 1 p1-6, 6p
Abstrakt: Pudendal nerve somatosensory evoked potentials (PN-SEPs), bulbo-cavernosus reflex (BC reflex) and perineal motor evoked potentials (BC MEPs) following transcranial magnetic cortical stimulation (TMS) were performed in patients with primary premature ejaculation (PPE), to investigate the somatic sensory and motor function of the genital area.Methods Fourteen patients with PPE underwent psychological counseling, urologic physical and trasnrectal ultrasound examination, laboratory data and Stamey test. Spinal and cortical PN-SEPs were recorded by dorsal nerve stimulaiton at penile shaft (DN-SEPs) in all patients, and at glans penis (GP-SEPs) in 3 of them. BC reflex was obtained by stimulating the basis of penis.Results Mean sensory thresold did not significantly differ between patients and normal subjects. Cortical DN-SEPs were normal in alla patients. Sensory central conduction was significantly smaller in patients than controls. In 3 patients and in 3 controls undergone both DN-SEPs and GP-SEPs, glans penis sensory threshold was lower than dorsal nerve one, and cortical GP-SEP latency longer than cortical DN-SEP latency. BC reflex was normal in most patients. BC MEPs were normal in all patients, but one.Conclusions We did not confirm either a faster conduction along the pudendal sensory pathway, or a greater cortical representation of the sensory stimuli from the genital area in oue patients. Moreover, we did not confirm an hyperexcitability of BC reflex in them. Our results suggest that the electrophysiological approach is probably not sufficient to clariphy the causes of PPE and more integrated investigation are requested.
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