| Autor: |
Muñoz-Leal, Sebastián, Faccini-Martínez, Álvaro A., Costa, Francisco B., Marcili, Arlei, Mesquita, Eric T.K.C., Marques, Edwaldo P., Labruna, Marcelo B. |
| Zdroj: |
Ticks and Tick-borne Diseases; May 2018, Vol. 9 Issue: 4 p864-871, 8p |
| Abstrakt: |
In South America, early reports from more than 50 years ago incriminated Ornithodoros rudisas vector of Borrelia venezuelensis,an agent of tick-borne relapsing fever (TBRF). Herein we report the rediscovery of O. rudisby means of morphological, biological and molecular analyses, which also comprise the first report of this tick species in Brazil. Phylogenetic analysis using partial fragments of mitochondrial 16S rRNA gene suggested that O. rudisforms a monophyletic group with Ornithodoros erraticus. By using laboratory rodents as hosts, we isolated a relapsing fever Borreliafrom an infected O. rudisfemale. Phylogenetic analysis inferred from the rrs, flaB, and glpQgenes of Borreliaspp. placed the spirochete harbored by O. rudisclosely related to Borrelia turicatae.Until further genetic evidence is not obtained we are referring to this O. rudisspirochete as B. venezuelensis. This is the first in vitro isolation of a TBRF Borreliafrom South America. The presence of O. rudisin Brazil should not be overlooked, since this tick has been historically implicated in human cases of TBRF in Colombia, Panama, and Venezuela. This study provides new reports of O. rudisand B. venezuelensisafter decades of scientific silence on these agents. |
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