Assessment of Plasma Proteomics Biomarker’s Ability to Distinguish Benign From Malignant Lung Nodules

Autor: Silvestri, Gerard A., Tanner, Nichole T., Kearney, Paul, Vachani, Anil, Massion, Pierre P., Porter, Alexander, Springmeyer, Steven C., Fang, Kenneth C., Midthun, David, Mazzone, Peter J., Silvestri, G.A., Leake, L., Mazzone, P., Beukemann, M., Midthun, D., McCarthy, P., Sigal, B., Deluca, T., Laberge, F., Fortin, B., Balaan, M., Dimitt, B., Pierre, A., Allison, F., Yarmus, L., Oakjones-Burgess, K., Tanner, N., Leake, L., Ettinger, N., Setchfield, T., Madtes, D., Hubbard, J., McConnell, W., Robinson, K., Lackey, A., Jacques, L., Kuo, E., Markland-Gentles, V., Massion, P., Muterspaug, A., Leach, J., Rothe, K., Rom, W., Pass, H., Sorenson, A., Chesnutt, A., Georgeson, A., Balekian, A., Fisher, J., Murali, R., Overton, A., Desai, N., Levesque, A., Krimsky, W., King, S., Vachani, A., Maletteri, K., Mileham, K., Carter, L., Hong, G., Ma, J., Voelker, K., Barrentine, H., Aronson, R., Henderson, M., Lamberti, J., Krawiecki, C., Case, A., Wilkins, L., Ayers, J.M., Fangmann, K., Landis, J., DeSouza, L., Hammoud, Z., Kah, D., Sanchez, J., Murdoch, L.
Zdroj: Chest; September 2018, Vol. 154 Issue: 3 p491-500, 10p
Abstrakt: Lung nodules are a diagnostic challenge, with an estimated yearly incidence of 1.6 million in the United States. This study evaluated the accuracy of an integrated proteomic classifier in identifying benign nodules in patients with a pretest probability of cancer (pCA) ≤ 50%.
Databáze: Supplemental Index