| Autor: |
Milne, Victoria E., Hoover, John P., Snider, Timothy A., Ko, Jeff C. H., Payton, Mark E. |
| Zdroj: |
Journal of Herpetological Medicine and Surgery; 2006, Vol. 16 Issue: 1 p20-26, 7p |
| Abstrakt: |
ABSTRACTHatchling green iguanas, Iguana iguana, weighing between 16 – 26 g were injected intracoelomically (ICe) with either propofol (n6) at an empirical 10 mg/kg dose or physiologic saline (0.9 sodium chloride) solution at 2 ml/kg as sham treatment controls (n3). Propofol effect from ICe administration was variable and induced mild sedation to a light plane of anesthesia in five of six iguanas based on their graded reflexes or responses (0 absent, 1 decreased and 2 normal) and had no measured effect in one iguana. Decreased graded responses were seen primarily in jaw tone and righting reflex. Tracheal intubation was possible in only one of the five (83) of six iguanas that responded. Analgesia was minimal or absent based on toe and vent pinch responses, and on corneal reflexes. Onset of maximum propofol effect was seen between five and 15 min post ICe propofol and provided 10 – 30 min of useful sedation or anesthesia. Heart rate and respiratory rate were measured for each iguana responding to propofol ICe at baseline (0 min), at the maximum effect and at recovery. Propofol ICe did not cause a significant decrease in heart rate at maximum effect or at recovery, but did cause a significant decrease in respiratory rate at maximum effect and recovery. There were no significant differences between the propofol and saline injected iguanas in the estimated total WBC at pre or 24 hr post ICe injection, or 14 d later at the time of euthanasia. All nine iguanas gained between 2 to 12.4 g (median 6.9 g) during this study and there was no significant difference in weight gains between Group 1 (mean of 7.0 g with median of 7.3 g) and Group 2 (mean of 8.3 g with median of 8.9 g) iguanas. No lesions attributable to ICe injections of either propofol or saline solution were seen on gross or histologic examinations. It appears that ICe propofol can induce sedation or light anesthesia and may be a viable and safe alternative to intravenous or intraosseous administration in small iguanas. An optimum or consistently effective dose for propofol administered ICe remains to be established. |
| Databáze: |
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