| Abstrakt: |
NODAL has been implicated in timing of parturition and immune regulation. We investigated the relationship between NODALpolymorphisms, infection/inflammation, and preterm birth. For this secondary analysis, 613 women (189 preterm and 424 term) from the Montreal Prematurity Study were genotyped for NODALpolymorphisms and assessed for bacterial vaginosis and placental inflammation. NODALpolymorphisms were not associated with preterm birth. However, the rs2231947(C>T) variant allele was associated with increased risk for preterm birth among women with bacterial vaginosis (odds ratio: 2.76, 95% confidence interval: 1.12−6.85). Among women without placental inflammation, the rs1904589(A>G) variant allele was associated with increased risk of preterm birth (odds ratio: 1.31, 95% confidence interval: 1.02−1.70). Among women with placental inflammation, the rs10999338(C>T) variant allele was associated with reduced risk of preterm birth (odds ratio: 0.50, 95% confidence interval: 0.29−0.87). The effect of NODALpolymorphisms on preterm birth depends on maternal infection/inflammation status. |
Full text from SpringerLink