Association between genetic polymorphisms of CYP2C9and VKORC1and safety and efficacy of warfarin: Results of a 5 years audit

Autor: Biswas, Mansij, Bendkhale, Shital R., Deshpande, Siddharth P., Thaker, Saket J., Kulkarni, Dwarkanath V., Bhatia, Shobna J., Rajadhyaksha, Anjali G., Gogtay, Nithya J., Thatte, Urmila M.
Zdroj: Indian Heart Journal; December 2018, Vol. 70 Issue: 1, Number 1 Supplement 3 pS13-S19, 7p
Abstrakt: Genetic polymorphisms of CYP2C9and VKORC1play major role in pharmacokinetics and pharmacodynamics of warfarin, respectively. Purpose of our study was to assess the utility of pretesting patients for the above mutations in predicting tendency for bleeding and achieving target INR.
Databáze: Supplemental Index