Macrocyclic Inhibitors of the NS3 Protease as Potential Therapeutic Agents of Hepatitis C Virus Infection Numerous scientists from Boehringer Ingelheim have contributed to the success of this project. In particular, we wish to acknowledge M. Poirier and J.-M. Ferland (for the synthesis of the macrocyclic inhibitors), N. Aubry (for assistance with the NMR studies), M. Marquis, A. Pause, and C. Pellerin (for their contribution to the replicon assay), D. Thibeault and R. Maurice (for the in vitro enzymatic assays and Ki determinations), C. Plouffe, S. Lefebvre, and H. Li (for purification of the NS3 protease and the specificity assays), A. Schmid (for expert help in crystallization and data collection), H. Bartunik (for access to the beamline BW6 at DESY), and F. Liard, M. Rhéaume, and M. Yazdanian (for their contributions to the metabolism, cell permeability, and PK studies). Finally, we are grateful to P. C. Anderson, M. B&

Autor:	Tsantrizos, Youla S., Bolger, Gordon, Bonneau, Pierre, Cameron, Dale R., Goudreau, Nathalie, Kukolj, George, LaPlante, Steven R., Llinàs-Brunet, Montse, Nar, Herbert, Lamarre, Daniel
Zdroj:	Angewandte Chemie. International Edition; March 28, 2003, Vol. 42 Issue: 12 p1356-1360, 5p
Abstrakt:	No Abstract
Databáze:	Supplemental Index
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