| Autor: |
Greiner, E., Prisinzano, T., Johnson, E. M., II, Dersch, C. M., Marcus, J., Partilla, J. S., Rothman, R. B., Jacobson, A. E., Rice, K. C. |
| Zdroj: |
Journal of Medicinal Chemistry; April 2003, Vol. 46 Issue: 8 p1465-1469, 5p |
| Abstrakt: |
A series of 4-[2-[bis(4-fluorophenyl)methoxy]ethyl-1-benzylpiperidines were examined for their ability to bind to the dopamine transporter (DAT), the serotonin transporter (SERT), and the norepinephrine transporter (NET). Binding results indicated that the presence of an electron-withdrawing group in the C4-position of the N-benzyl group is beneficial for binding to the DAT. Several analogues have been identified with high affinity for the DAT, up to 500-fold selectivity over the SERT and about 170-fold selectivity over the NET in binding and uptake inhibition assays. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
